Elsevier S & T

The Immune Response: Basic and Clinical Principles

Mak, Tak W.; Saunders, Mary E.

In stock

No reviews

77.750 KD inc. VAT

License

perpetual

Table of contents

Contentsxiii
Prefacevii
Biographiesix
Acknowledgmentsxi
Part I: Basic Immunology1
Chapter 1. Perspective on Immunity and Immunology3
A. What Is Immunology?4
B. Why Have an Immune System and What Does It Do?7
C. Types of Immune Responses: Innate and Adaptive7
D. What Is "Infection"?10
E. Phases of Host Defense11
F. How Are Adaptive and Innate Immunity Related?12
G. Leukocytes: Cellular Mediators of Immunity13
H. Where Do Immune Responses Occur?14
I. Clinical Immunology: When the Immune System Does Not Work Properly15
Chapter 2. Introduction to the Immune Response17
A. General Features of Innate Immunity18
B. General Features of Adaptive Immunity19
C. Elements of Immunity Common to the Innate and Adaptive Responses22
D. Elements of Immunity Exclusive to the Adaptive Response24
Chapter 3. Cells and Tissues of the Immune Response35
A. Cells of the Immune System36
B. Lymphoid Tissues51
Chapter 4. Innate Immunity69
A. Mechanisms of Innate Immunity70
B. Pattern Recognition in Innate Immunity84
Chapter 5. B Cell Receptor Structure and Effector Function93
A. Historical Notes94
B. The Structure of Immunoglobulins97
C. Effector Functions of Antibodies113
D. Immunoglobulin Isotypes in Biological Context116
Chapter 6. The Nature of Antigen–Antibody Interaction121
A. The Nature of B Cell Immunogens122
B. B Cell–T Cell Cooperation in the Humoral Immune Response130
C. The Mechanics of Antigen–Antibody Interaction137
Chapter 7. Exploiting Antigen–Antibody Interaction147
A. Sources of Antibodies149
B. Techniques Based on Immune Complex Formation155
C. Assays Based on Unitary Antigen–Antibody Pair Formation162
Chapter 8. The Immunoglobulin Genes179
A. Historical Notes180
B. Chromosomal Organization of Ig Genes183
C. Ig Gene Rearrangement188
D. Molecular Mechanisms of Ig Gene Rearrangement196
E. Antibody Diversity Generated by Gene Rearrangement201
F. Control Sequences in the Ig Loci204
Chapter 9. The Humoral Response: B Cell Development and Activation209
A. The Maturation Phase of B Cell Development211
B. The Differentiation Phase of B Cell Development217
Chapter 10. MHC: The Major Histocompatibility Complex247
A. Historical Notes248
B. General Aspects of the MHC in Humans and Mice254
C. MHC Proteins260
D. MHC Genes264
E. Expression of MHC Molecules269
F. Physiology of the MHC272
Chapter 11. Antigen Processing and Presentation279
A. The Exogenous or Endocytic Antigen Processing Pathway281
B. The Endogenous or Cytosolic Antigen Processing Pathway295
C. Other Pathways of Antigen Presentation302
Chapter 12. The T Cell Receptor: Structure of Its Proteins and Genes311
A. Historical Notes312
B. The Structure of T Cell Receptor Proteins317
C. Genomic Organization of the TCR and CD3 Loci319
D. Expression of TCR Genes322
E. Developmental Aspects of V(D)J Recombination in the TCR Loci325
F. Generation of Diversity of the T Cell Receptor Repertoire327
G. Regulation of TCR Gene Expression329
H. Structure and Function of the CD3 Complex330
I. The CD4 and CD8 Coreceptors332
J. Physical Aspects of the Interaction of the TCR with Antigen336
Chapter 13. T Cell Development341
A. Historical Notes342
B. Context and Overview344
C. T Cell Development in the Bone Marrow347
D. T Cell Development in the Thymus347
E. Mature SP Thymocytes in the Periphery368
F. T Cell Development in an Embryological Context368
Chapter 14. T Cell Activation373
A. Bringing T Cells and APCs Together375
B. Signal One: Binding of Peptide–MHC to the TCR378
D. Signal Three: Cytokines398
Chapter 15. T Cell Differentiation and Effector Function403
A. Historical Notes404
B. Th Cell Differentiation and Effector Function405
C. Tc Cell Differentiation and CTL Effector Function417
D. Comparison of Naive and Effector T Cells422
E. Elimination of Effector T Cells424
F. Memory T Cells427
Chapter 16. Immune Tolerance in the Periphery433
A. Context of Peripheral Tolerance434
B. T Cell Peripheral Self-Tolerance437
C. B Cell Peripheral Self-Tolerance447
D. Regulatory T Cells450
E. Experimental Tolerance454
Chapter 17. Cytokines and Cytokine Receptors463
A. Historical Notes464
B. Overview465
C. Function, Production, and Receptors of Cytokines469
D. Cytokines and Their Receptors in Physiological Context508
Chapter 18. Bridging Innate and Adaptive Immunity: NK, γδ T, and NKT Cells517
A. Natural Killer (NK) Cells518
B. γδ T Cells537
C. NKT Cells547
Chapter 19. Complement553
A. Historical Notes554
B. Overview of the Complement System555
C. The Classical Pathway of Complement Activation557
D. The Alternative Pathway of Complement Activation561
E. The Lectin Pathway of Complement Activation562
F. Terminal Components of the Complement Cascade and Formation of the MAC564
G. Regulation of the Complement System566
H. Complement Receptors and Their Biological Roles572
I. Complement Deficiencies575
J. New Roles for Complement?579
Chapter 20. Mucosal and Cutaneous Immunity583
A. Mucosal Immunity584
B. Cutaneous Immunity600
Chapter 21. Comparative Immunology611
A. Overview612
B. Elements of Innate Immunity618
C. Elements of Adaptive Immunity626
Part II: Clinical Immunology639
Chapter 22. Immunity to Pathogens641
A. Overview642
B. Immunity to Extracellular Bacteria647
C. Immunity to Intracellular Bacteria656
D. Immunity to Viruses664
E. Immunity to Parasites680
F. Immunity to Fungi688
G. The Mysterious Prions691
Chapter 23. Vaccines and Clinical Immunization695
A. Vaccination: Public Health Successes and Challenges696
B. Historical Notes698
C. General Principles of Vaccine Design703
D. Types of Vaccines705
E. Factors Affecting Vaccination718
F. Prophylactic Vaccines727
G. The "Dark Side" of Vaccines739
H. Prophylactic Vaccines of the Future740
I. Passive Immunization741
J. Therapeutic Vaccines744
Chapter 24. Primary Immunodeficiencies751
A. General Concepts752
B. Primary Immunodeficiencies Due to Defects in Adaptive Immune Responses754
C. Primary Immunodeficiencies Due to Defects in the Innate Immune Response776
Chapter 25. HIV And Acquired Immunodeficiency Syndrome785
A. Historical Notes786
B. What is HIV?788
C. Structure and Function of HIV Proteins791
D. HIV Infection and AIDS796
E. The Immune Response during HIV Infection802
F. Host Factors Influencing the Course of HIV Infection805
G. Epidemiology and Sociology of HIV Infection808
H. Animal Models of AIDS813
I. HIV Vaccines815
J. Treatment of HIV Infection with Anti-retroviral Drugs819
Chapter 26. Tumor Immunology825
A. Historical Notes826
B. Tumor Biology829
C. Immune Responses to Cancer842
D. Cancer Therapy851
Chapter 27. Transplantation873
A. Historical Notes874
B. The Molecular Basis of Allorecognition880
C. Minor Histocompatibility Antigens881
D. Types of Clinical Rejection and Their Mechanisms885
E. HLA Typing890
F. Immunosuppression896
G. Induction of Graft Tolerance899
H. Xenotransplantation906
I. Blood Transfusions910
J. Hematopoietic Cell Transplantation (HCT)913
K. Gene Therapy in Transplantation917
Chapter 28. Allergy and Hypersensitivity923
A. Historical Notes924
B. Type I Hypersensitivity: Immediate or IgE-Mediated925
C. Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxicity949
D. Type III Hypersensitivity: Immune Complex-Mediated Injury954
E. Type IV Hypersensitivity: Delayed-Type or Cell-Mediated Hypersensitivity957
Chapter 29. Autoimmune Disease963
A. Overview964
B. Examples of Human Autoimmune Diseases969
C. Animal Models of Autoimmune Disease986
D. Determinants of Autoimmune Disease995
E. Mechanisms Underlying AID1001
F. Therapy of AID1012
G. Relationship between AID and Cancer1020
Chapter 30. Hematopoietic Cancers1025
A. Historical Notes1026
B. Overview of Hematopoietic Cancer Biology1027
D. Leukemias1035
E. Plasma Cell Dyscrasias1046
F. Lymphomas1050
Appendix: CD Molecules1065
Glossary1119
Index1179

Book details

Vendor Elsevier S & T
SKU 9780120884513
ISBN-13 9780080534480
Author Mak, Tak W.; Saunders, Mary E.
Category Medical
Subject Immunology

Do you have questions about this book?

Ask an expert!

The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences.

* Current and thorough 30 chapter reference reviewed by luminaries in the field
* Unique ‘single voice' ensures consistency of definitions and concepts
* Comprehensive and elegant illustrations bring key concepts to life
* Provides historical context to allow fuller understanding of key issues
* Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail
* Includes a companion website containing all the figures and plates appearing in the book

Instant delivery by email
Your access email arrives within minutes of checkout, with a sign-in link for each book — no shipping, no waiting.

Read on any device
Books open in VitalSource Bookshelf on your phone, tablet, or computer, online or offline. Your library is always available at aafaq.vitalsource.com — just log in with the email you used at checkout.

Lost the email?
Resend it to yourself in seconds from My eBook orders, or email cs@aafaqeducation.com and we'll help.