Elsevier S & T

The Mitochondrion in the Germline and Early Development

St. John, Justin

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Table of contents
  • The Mitochondrion in the Germline and Early Developmentiii
  • Copyright Pageiv
  • Contentsv
  • Contributorsix
  • Prefacexiii
  • Section I: The Mitochondrion and Gametes1
  • Chapter 1: The Role of the Mitochondrion in Sperm Function: Is There a Place for Oxidative Phosphory3
  • I. Introduction3
  • II. Spermiogenesis: Removing Everything But the Essential4
  • III. Sperm Mitochondria Are Required for Functional Purposes6
  • IV. Is Glycolysis Required for Sperm Motility?9
  • V. Substrates Available for the Supply of Energy11
  • VI. Concluding Remarks13
  • Acknowledgments14
  • References14
  • Chapter 2: The Role of Mitochondrial Function in the Oocyte and Embryo21
  • Abbreviations22
  • I. Introduction22
  • II. Mitochondrial Generation and Distribution in Eggs and Embryos25
  • III. Studying Mitochondria in Eggs and Embryos27
  • IV. Mitochondria and Energy Production in the Embryo31
  • V. Mitochondria and Ca2+ Homeostasis in Eggs and Embryos33
  • VI. Ca2+-Induced Mitochondrial Activity: Matching ATP Supply and Demand34
  • VII. Mitochondria and Redox Metabolism in the Embryo34
  • VIII. Impact of Mitochondrial Activity on Embryonic Development37
  • IX. Mitochondria and Apoptosis in the Embryo40
  • X. Conclusions and Perspectives41
  • Acknowledgments42
  • References42
  • Chapter 3: Mitochondrial DNA in the Oocyte and the Developing Embryo51
  • I. Introduction52
  • II. Mitochondrial DNA Structure and Function54
  • III. mtDNA Content in Oocytes57
  • IV. Variation of mtDNA Content and Transcripts in Early Embryonic Development65
  • V. mtDNA Mutations in Oocytes and Embryos71
  • VI. Conclusions and Perspectives74
  • References74
  • Section II: Transmission85
  • Chapter 4: Mitochondrial DNA and the Mammalian Oocyte87
  • I. Introduction88
  • II. mtDNA: Structure, Organization, Replication, and Expression89
  • III. Origin and Development of the Germ Line92
  • IV. Transmission of mtDNA in the Female Germ Line95
  • V. OXPHOS, Atresia, and Oocyte Quality98
  • VI. mtDNA Copy Number in the Oocyte99
  • VII. Male Transmission of mtDNA101
  • VIII. Clinical Perspectives103
  • IX. Conclusions and Future Prospects105
  • Acknowledgments106
  • References106
  • Chapter 5: Mitochondrial Disease„Its Impact, Etiology, and Pathology113
  • I. Introduction114
  • II. Mitochondrial Genetics116
  • III. Impact123
  • IV. Etiology129
  • V. Pathology137
  • VI. Conclusions143
  • Acknowledgments143
  • References143
  • Chapter 6: Cybrid Models of mtDNA Disease and Transmission, from Cells to Mice157
  • I. What Can Be Learned from Cybrids About mtDNA Disease?158
  • II. Animal Modeling of mtDNA Transmission and Human Disease: From Transgenesis to Transmitochondrial169
  • III. Summary176
  • References176
  • Section III: The Use of Assisted Reproductive Technologies to Regulate mtDNA Disease185
  • Chapter 7: The Use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated M187
  • I. Biological Material: Oocytes and Zygotes188
  • II. Technical Equipment189
  • III. Germinal Vesicle Transfer190
  • IV. Short- and Long-Term Storage of Nuclear Material and Asynchronous GV to Cytoplast Transfer194
  • V. Chromosome Group Transfer198
  • VI. Transfer of Pronuclei203
  • VII. Conclusions207
  • Acknowledgments207
  • References208
  • Chapter 8: Difficulties and Possible Solutions in the Genetic Management of mtDNA Disease in the Pre213
  • I. Heteroplasmy of mtDNA Presents Problems for Chorionic Villus Sampling214
  • II. The Mitochondrial Bottleneck217
  • III. Management Options Beyond CVS220
  • References223
  • Section IV: The Effects of Invasive Assisted Reproductive Technologies on mtDNA Transmission227
  • Chapter 9: Impact of Assisted Reproductive Technologies: A Mitochondrial Perspective of Cytoplasmic229
  • I. Why Are Invasive Assisted Reproductive Technology Procedures Important?230
  • II. Cytoplasmic Transfer: Animal Models That May Assist Human Infertility Therapeutics232
  • III. The Mitochondrial Genome and Mitochondrial Biogenesis233
  • IV. Molecular Control of Mitochondrial Function in Preimplantation Embryos237
  • V. Mitochondrial Copy Number, Deletions, and Mutations239
  • VI. Oocyte and Embryo Mitochondrial Localization Patterns242
  • VII. Implications of Mitochondrial Heteroplasmy in Infertility, Mitochondrial Disease, and Stem Cell243
  • References244
  • Chapter 10: Nuclear Transfer: Preservation of a Nuclear Genome at the Expense of Its Associated mtDN251
  • I. Introduction252
  • II. Adaptations to NT252
  • III. Applications of NT255
  • IV. Health Problems Associated with NT257
  • V. Possible Causes of NT Failure258
  • VI. Are All the Potential Reasons for Low Success Rates in NT Interlinked?274
  • VII. Conclusions277
  • References277
  • Index291
  • Contents of Previous Volumes307
Book details
  • Vendor Elsevier S & T
  • SKU 9780123736628
  • ISBN-13 9780080471136
  • Author St. John, Justin
  • Category Science
  • Subject Molecular Biology

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Description eBook delivery & access Reviews
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

* Includes many descriptive figures
* Topics covered include the role of mitochondrial function, the use of ARTs to regulate mtDNA disease, nuclear transfer, and more
* Latest volume in the series that covers 10 reviews from leading authorities in developmental biology