Elsevier S & T

The Parathyroids: Basic and Clinical Concepts

Bilezikian, John P.; Marcus, Robert; Levine, Michael A.

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Table of contents

Contentsv
Contributorsix
Preface to the Second Editionxv
Preface to the First Editionxvii
Section I: Basic Elements of the Parathyroid System1
Chapter 1. Parathyroids: Morphology and Pathology1
Chapter 2. Parathyroid Hormone Biosynthesis and Metabolism17
Chapter 3. Parathyroid Hormone-Related Protein: Gene Structure, Biosynthesis, Metabolism, and Regula31
Chapter 4. Interactions of Parathyroid Hormone and Parathyroid Hormone-Related Protein with Their Re53
Chapter 5. Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Protein: Signaling and93
Chapter 6. Nuclear Actions of PTHrP105
Chapter 7. Signal Transduction of PTH and PTHrP117
Chapter 8. Receptors and Signaling for Calcium Ions127
Chapter 9. Immunoassays for PTH and PTHrP: Clinical Applications143
Section II: Physiological Aspects of the Parathyroid167
Chapter 10. Physiology of Calcium Homeostasis167
Chapter 11. Parathyroid Hormone. Anabolic and Catabolic Effects on Bone and Interactions with Growth183
Chapter 12. Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation199
Chapter 13. Physiologic Actions of PTH and PTHrP: I. Skeletal Actions213
Chapter 14. Physiologic Actions of PTH and PTHrP: II. Renal Actions227
Chapter 15. Endochondral Bone Formation: Regulation by Parathyroid Hormone-Related Peptide, Indian H245
Chapter 16. Physiologic Actions of PTH and PTHrP: IV. Vascular,Cardiovascular,and Neurologic Actions261
Chapter 17. Physiologic Actions of PTH and PTHrP: V. Epidermal, Mammary, Reproductive,and Pancreatic275
Section III: Clinical Aspects of Primary Hyperparathyroidism293
Chapter 18. Parathyroid Growth: Normal and Abnormal293
Chapter 19. Molecular Basis of Primary Hyperparathyroidism331
Chapter 20. Clinical Presentation of Primary Hyperparathyroidism in the United States349
Chapter 21. Clinical Presentation of Primary Hyperparathyroidism: Europe361
Chapter 22. Clinical Presentation of Primary Hyperparathyroidism: India, Brazil, and China375
Chapter 23. Clinical Course of Primary Hyperparathyroidism387
Chapter 24. Molecular Markers of Bone Metabolism in Parathyroid Disease399
Chapter 25. Cytokines in Primary Hyperparathyroidism411
Chapter 26. Histomorphometric Analysis of Bone in Primary Hyperparathyroidism423
Chapter 27. Nephrolithiasis in Primary Hyperparathyroidism437
Chapter 28. Guidelines for the Medical and Surgical Management of Primary Hyperparathyroidism451
Chapter 29. Medical Management of Primary Hyperparathyroidism459
Chapter 30. Preoperative Localization of Parathyroid Tissue in Primary Hyperparathyroidism475
Chapter 31. The Surgical Management of Hyperparathyroidism487
Chapter 32. Ectopic Locations of Parathyroid Glands499
Chapter 33. Parathyroid Carcinoma515
Chapter 34. Acute Primary Hyperparathyroidism527
Chapter 35. Multiple Endocrine Neoplasia Type 1535
Chapter 36. Multiple Endocrine Neoplasia Type 2585
Chapter 37. Familial Forms of Primary Hyperparathyroidism601
Chapter 38. Familial Benign Hypocalciuric Hypercalcemia and Neonatal Severe Hyperparathyroidism607
Section IV: Secondary Hyperparathyroidism625
Chapter 39. The Parathyroids in Renal Disease: Pathophysiology625
Chapter 40. Renal Bone Diseases: Clinical Features, Diagnosis, and Management635
Section V: Special Considerations663
Chapter 41. Evaluation of the Hypercalcemic Patient: Differential Diagnosis663
Chapter 42. Hypercalcemia Due to PTHrP671
Chapter 43. Other Local and Ectopic Hormone Syndromes Associated with Hypercalcemia691
Chapter 44. Genetic Disorders Caused by Mutations in the PTH/PTHrP Receptor: Jansen's Metaphyseal Ch707
Chapter 45. Acute Management of Hypercalcemia729
Chapter 46. Primary Hyperparathyroidism and Other Causes of Hypercalcemia in Children and Adolescent743
Section VI: The Hypoparathyroid States755
Chapter 47. Hypoparathyroidism in the Differential Diagnosis of Hypocalcemia755
Chapter 48. Magnesium Deficiency in Parathyroid Function763
Chapter 49. The Molecular Genetics of Hypoparathyroidism779
Chapter 50. Autoimmune Hypoparathyroidism791
Chapter 51. Pseudohypoparathyroidism: Clinical, Biochemical, and Molecular Features807
Chapter 52. Treatment of Hypoparathyroidism827
Section VII: The Parathyroids in Osteoporosis835
Chapter 53. Parathyroid Function in the Normal Aging Process835
Chapter 54. Parathyroid Function and Responsiveness in Osteoporosis843
Chapter 55. Parathyroid Hormone and Growth Hormone in the Treatment of Osteoporosis853
Index865
Color Plate SectionPlate1

Book details

Vendor Elsevier S & T
SKU 9780120986514
ISBN-13 9780080525778
Author Bilezikian, John P.; Marcus, Robert; Levine, Michael A.
Edition 2nd
Category Medical
Subject Endocrinology & Metabolism

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Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians.

Key Features
* Offers objective and authoritative reviews on controversial clinical issues
* Written by world experts on parathyroid hormone and its disorders
* Superb, state-of-the-art compendium in one convenient volume
* Bridges basic science of parathyroid hormone to major clinical disorders
* Practical information on clinical management of parathyroid hormone disorders

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