The Quinolones
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Table of contents
- Contentsv
- Contributorsxv
- Prefacexix
- Chapter 1. The Quinolones: History and Overview1
- Introduction2
- Antibacterial Activity6
- Bacterial Resistance To Fluoroquinolones8
- Clinical Pharmacology9
- Clinical Uses12
- Pharmacoeconomic Aspects of Fluoroquinolone Usage16
- Use of Fluoroquinolones in Pediatrics17
- Adverse Drug Reactions19
- Interactions with Other Drugs22
- Conclusion23
- References24
- Chapter 2. Chemistry and Mechanism of Action of the Quinolone Antibacterials33
- Introduction34
- Structural and Historical Background34
- Third- and Fourth-Generation Quinolones42
- Future Directions57
- Mechanism of Action61
- Conclusion81
- References82
- Chapter 3. Comparative In-Vitro Properties of the Quinolones99
- Introduction99
- Gram-Negative Aerobes102
- Gram-Positive Aerobes117
- Anaerobes125
- Miscellaneous Organisms130
- Conclusion132
- References132
- Chapter 4. Bacterial Resistance to Quinolones:Mechanisms and Clinical Implications139
- Introduction140
- Mechanisms of Quinolone Resistance140
- Gram-Negative Bacteria140
- Gram-Positive Bacteria146
- Clinical Impact of Bacterial Resistance to Quinolones149
- References156
- Chapter 5. Pharmacokinetics and Pharmacodynamics of the Fluoroquinolones169
- Introduction170
- Basic Concepts of Pharmacokinetics and Pharmacodynamics170
- Pharmacokinetics171
- Pharmacodynamics185
- Conclusion191
- References191
- Chapter 6. Use of Quinolones in Urinary Tract Infection and Prostatitis203
- Introduction203
- Urinary Tract Infection204
- Pharmacology207
- Microbiology207
- Clinical Studies209
- Conclusion218
- References218
- Chapter 7. Use of the Quinolones in Sexually Transmitted Diseases227
- Introduction228
- Gonococcal Infections229
- Chlamydia trachomatics235
- Pelvic Inflammatory Disease238
- Chancroid239
- Donovanosis241
- Bacterial Vaginosis241
- Special Toxicity Considerations When Quinolones are Used For Treating Sexually Transmitted Diseases242
- Conclusion243
- References243
- Chapter 8. Treatment of Respiratory Infections with Quinolones255
- Introduction255
- Clinical Issues in the Therapy of Respiratory Infection257
- Pharmacological Advantages for the Use of Quinolones in Respiratory Infection262
- Microbiologic Advantages of Quinolones for Respiratory Infection267
- Clinical Efficacy of Quinolones for The Therapy of Respiratory Tract Infections271
- Conclusion276
- References277
- Chapter 9. Use of Quinolones in Surgery and Obstetrics and Gynecology285
- Introduction285
- Surgical Wound Prophylaxis286
- Soft Tissue Infection288
- Intraabdominal Infection289
- Gynecologic Infections291
- Postoperative Pelvic Infections293
- Pelvic Inflammatory Disease294
- Upper Genital Tract Infection295
- Pregnancy296
- Conclusion297
- References297
- Chapter 10. Use of the Quinolones for Treatment and Prophylaxis of Bacterial Gastrointestinal Infect303
- Introduction304
- Clinical Studies305
- Antimicrobial Resistance to Quinolones316
- Conclusion317
- References318
- Chapter 11. Use of the Quinolones in Treatment of Bacterial Meningitis325
- Introduction325
- Pharmacology326
- Microbiology335
- Studies of Clinical Efficacy336
- Conclusion339
- References339
- Chapter 12. Use of the Quinolones in Immunocompromised Patients343
- Introduction343
- Risk Factors and Associated Infections344
- Rationale for Fluoroquinolone Use346
- Effect of Fluoroquinolones on Endogenous Microflora347
- Infection Prevention in Afebrile Neutropenic Patients348
- Empiric Therapy in Febrile Neutropenic Patients350
- Risk-Based Therapy for Febrile Neutropenia352
- Treatment Of Specific Infections354
- Conclusion359
- References360
- Chapter 13. Use of the Quinolones in Skin and Skin structure (Osteomyelitis) and Other Infections371
- Introduction371
- Skin and Soft Tissue Infection372
- Bone and Joint Infection378
- Conclusion389
- References390
- Chapter 14. Safety Overview: Toxicity, Adverse Effects,and Drug Interactions397
- Introduction398
- Toxicity Of Quinolones (Studies in Animals)399
- Adverse Effects of Fluoroquinolones in Clinical Studies413
- Drug Interactions433
- References442
- Chapter 15. Use of the Quinolones in Pediatrics455
- Introduction455
- Animal Data456
- Pharmacokinetics460
- Clinical Experiences460
- Newest Compounds467
- Recommendations468
- Conclusion468
- References469
- Chapter 16. The Quinolones: Prospects477
- Introduction477
- Molecular Mechanisms of The Quinolones: Key Discoveries478
- Microbiology480
- Pharmacokinetics481
- Clinical Uses482
- Adverse Events483
- Quinolones: Future Developments486
- Current Quinolone Status and Classification487
- Conclusion490
- References491
- Index497
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual struggle to conquer disease.
Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research.
Edited by one of the world's foremost authorities on the subject, the third edition of this highly successful title will serve as a valuable tool for primary care physicians and researchers interested in a comprehensive, up-to-date reference on the chemistry, mechanisms of action, development of resistance, and clinical efficacy of both currently available and newer quinolone compounds under investigation. This is the eagerly anticipated fully revised edition of the standard reference in the field.
Key Features
* Eagerly anticipated updated edition of noted title covering synthetic microbial agents that are useful against infectious disease, particularly those caused by bacteria
* Edited by one of the foremost experts in the field of quinolone research and infectious disease
* History of quinolones, chemistry & mechanisms of action, pharmacology, safety aspects
* Role of quinolones in treating various types of infections, including respiratory infections, gastrointestinal infections, urinary tract infections, prostatitis, STDs and bacterial meningitis as well as their use in immunocompromised patients
Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research.
Edited by one of the world's foremost authorities on the subject, the third edition of this highly successful title will serve as a valuable tool for primary care physicians and researchers interested in a comprehensive, up-to-date reference on the chemistry, mechanisms of action, development of resistance, and clinical efficacy of both currently available and newer quinolone compounds under investigation. This is the eagerly anticipated fully revised edition of the standard reference in the field.
Key Features
* Eagerly anticipated updated edition of noted title covering synthetic microbial agents that are useful against infectious disease, particularly those caused by bacteria
* Edited by one of the foremost experts in the field of quinolone research and infectious disease
* History of quinolones, chemistry & mechanisms of action, pharmacology, safety aspects
* Role of quinolones in treating various types of infections, including respiratory infections, gastrointestinal infections, urinary tract infections, prostatitis, STDs and bacterial meningitis as well as their use in immunocompromised patients