The Somatotrophic Axis in Brain Function
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Table of contents
- The Somatotrophic Axis in Brain Functioniii
- Contentsv
- Prefacevii
- Contributorsix
- Pioneers in the growth hormone fieldxi
- Introduction1
- Section I: Biosynthesis of GH and IGF-I and Regulation of Their Secretion5
- Chapter 1. Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis7
- Chapter 2. Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor25
- Section II: GH and IGF-I and their Function at Receptor Level37
- Chapter 3. Mechanisms of Signal Transduction Utilized by Growth Hormone39
- Chapter 4. Insulin-like Growth Factor-I and its Binding Proteins: Regulation of Secretion and Mechan51
- Section III: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervo67
- Chapter 5. Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid69
- Chapter 6. Growth Hormone, Insulin, and IGF-I: Do They Interact at the Blood–Brain Barrier?75
- Chapter 7. Growth Hormone and Insulin-like Growth Factors in the CNS: Localisation in Mammalian Spec81
- Chapter 8. Purification of Growth Hormone Receptors from Human Brain Tissues91
- Chapter 9. Growth Hormone Receptor Message in the Rat and Human CNS: Structure and Function99
- Section IV: CNS Action of Growth Hormone: Basic Studies Using Animal Models109
- Chapter 10. Interaction of Growth Hormone and Prolactin in Brain Circuits111
- Chapter 11. Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult B125
- Chapter 12. Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junc147
- Chapter 13. Rodent Models for the Study of the Role of GH–IGF-I or the Insulin Axis in Aging and L173
- Chapter 14. Growth Hormone and Insulin-like Growth Factor-I (IGF-I) and Their Interactions with Brai185
- Chapter 15. IGF-I and Neuroprotection209
- Section V: Immediate and Long-Term Benefits on the CNS and GH Replacement Therapy217
- Chapter 16. Quality of Life in Adult GH Deficiency219
- Chapter 17. The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology231
- Chapter 18. Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality237
- Chapter 19. Psychological Importance to the Child of Growth Hormone Replacement249
- Chapter 20. Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increas267
- Chapter 21. Human Aging and the Growth Hormone/Insulin-like Growth factor-I axis: The Impact of Grow271
- Chapter 22. Cognitive Status of Adult GHD Patients and GH-Induced Neuropsychological Changes287
- Chapter 23. Growth Hormone and Insulin-like Growth Factor-I in Alzheimer’s Disease301
- Section VI: GH Replacement and Related Therapies in CNS Disorders: A Future Perspective311
- Chapter 24. Growth Hormone Antagonists – A Pharmacological Tool in Present and Future Therapies313
- Chapter 25. Growth Hormone Replacement Therapy and Life Quality: Future Perspectives327
- Index335
- Color Plate SectionColor Plat
The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.
This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.
Contents are well balanced and cover a variety of relevant topics from basic to clinical research
International selection of authors, with a good representation of the research on growth hormones
A timely publication which will be useful to scientists in both basic and clinical research
This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.
Contents are well balanced and cover a variety of relevant topics from basic to clinical research
International selection of authors, with a good representation of the research on growth hormones
A timely publication which will be useful to scientists in both basic and clinical research