Translation of Addictions Science Into Practice
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Table of contents
- Copyright pageiv
- Table of Contentsv
- List of Contributorsix
- Prefacexiii
- Section I: Genetics and Neuroscience1
- Chapter 1. The Interplay between Genotype and Gene Expression in Human Brain: What Can it Teach Us a3
- Drug and Alcohol Abuse4
- Future Directions15
- Concluding Remarks16
- Acknowledgments17
- References17
- Chapter 2. Common Genetic Influences on Antisociality and Addictions: Implications for Clinical Scie23
- Comorbidity of Addictions and Antisociality: An Introduction24
- Shared Genetic Vulnerabilities to Antisociality and Addictions26
- Molecular Genetics of Antisociality and Addictions: Examples from the Study of Alcoholism29
- Implications of Common Genetic Influences of Antisocial Personality and Addictions for Conceptualizi30
- From Genes to Clinical Practice: Implications of Genetic Research for Advancing Clinical Care32
- Summary and Conclusions35
- References36
- Chapter 3. Opioids, Pain and Addiction: Cause and Consequence39
- Opioid-Induced Hyperalgesia40
- Implications for Opioid Dependence Treatment45
- Future Directions48
- General Conclusion52
- References53
- Chapter 4. Imbalance between Neuroexcitatory and Neuroinhibitory Amino Acids causes Craving for Etha57
- Introduction58
- Effects of Ethanol on Glutamate58
- Ethanol Withdrawal60
- Multiple Ethanol Withdrawal62
- Acamprosate and Repeated Ethanol Withdrawal64
- Conditioning Associated with Ethanol65
- Excitatory Amino Acids and Ethanol in Humans70
- Clinical Implications74
- References75
- Chapter 5. Cannabis and the Brain: Implications of Recent Research81
- Psychiatric Symptoms Associated with Cannabis82
- Cannabis and Schizophrenia84
- Summary and Future Directions94
- References95
- Section II: Pharmacotherapy101
- Chapter 6. The Plasticity of Alcohol Addiction Suggests Novel Approaches to Pharmacological Interven103
- Neurobiology of Alcohol Addiction105
- Glutamatergic System105
- Glutamate and Alcohol106
- Ethanol and the Post-Synaptic Density110
- Metabotropic Glutamate Receptors112
- References116
- Chapter 7. Pharmacotherapies for the Treatment of Alcohol Dependence: Current and on the Horizon123
- Epidemiology124
- Alcohol Withdrawal and Detoxification125
- Relapse Prevention126
- Disulfiram126
- Naltrexone128
- Acamprosate130
- Treatment Options on the Horizon132
- Medication Compliance and Its Impact on Alcohol Pharmacotherapy134
- Conclusions and Future Directions136
- References138
- Chapter 8. Agonist Treatment for Stimulant Abuse and Dependence145
- Relevant Science, Introduction and Background146
- Immediate Implications for Prevention, Assessment or Treatment Developments148
- Speculation on Future Directions for Translational Developments152
- References160
- Chapter 9. Topiramate-Induced Neuromodulation of Cortico-Mesolimbic Dopamine: Implications for the T169
- Nicotine and Alcohol Dependence:The Problem of Comorbidity170
- Topiramate: A Promising new Vista173
- The Clinical Experience177
- Conclusions179
- Acknowledgments180
- References180
- Section III: Psychology and Sociology187
- Chapter 10. Advances in the Scientific Study of Craving for Alcohol and Tobacco189
- Introduction190
- Advances in the Scientific Study of Craving191
- Research Priorities in the Scientific Study of Craving198
- Future Directions in the Scientific Study of Craving200
- Summary and Conclusions202
- References202
- Chapter 11. Advances in the Treatment of Craving for Alcohol and Tobacco211
- Introduction212
- Contemporary Science-Based Clinical Approaches to Craving212
- Priorities for Improving the Contemporary Treatment of Craving220
- Future Directions in the Treatment of Craving224
- Summary and Conclusions229
- References230
- Chapter 12. Cognitive, Affective and Motivational Effects of Smoking239
- Nicotine Pharmacology and Mechanisms of Action240
- Cognitive Correlates of Smoking and Abstinence from Smoking241
- Psychological/Affective Correlates of Smoking and Abstinence from Smoking242
- References253
- Chapter 13. Therapeutic Outcome Research and Dissemination of Empirically Based Treatment for Alcoho259
- Brief History of Problem260
- Treatments that Work260
- Dissemination/Implementation264
- The Macro Level: Efforts to Promote Evidence-Based Practices Among Community Counselors265
- The Micro-Level: Clinical Training as a Necessary, But Insufficient Ingredient for Sustained Clinica268
- The Efficacy and Effectiveness of Clinical Training269
- Training Alone is Insufficient to Promote Sustained Change in Clinical Practice271
- Conclusion272
- References273
- Chapter 14. Implications of Research on Comorbidity for the Nature and Management of Substance Misus277
- Models of Comorbidity279
- Genetic Factors279
- Antisocial Personality Disorder (ASPD)280
- Secondary Psychiatric Illness Models284
- Bidirectional Models286
- Treatment of Co-occurring Disorders287
- Future Directions for Translational Research310
- References312
- Chapter 15. The Role of Impulsive Personality Traits in the Initiation, Development, and Treatment o321
- The Role of Impulsive Personality Traits in the Initiation, Development,and Treatment of Substance M322
- The Dimensions of Impulsivity323
- Current Models of Impulsivity and Substance Misuse324
- Evidence Supporting the Association between Reward Drive and Substance Use325
- Evidence Supporting the Association between Rash Impulsiveness and Substance Use326
- The Role of Reward Drive and Rash Impulsiveness in the Initiation of Substance Use327
- Implications for the Prevention and Treatment of Adolescent Substance Use329
- The Impact of Chronic Substance use on Dimensions of Impulsivity330
- Implications for the Treatment of Substance Abuse and Dependence332
- Conclusion333
- References334
- Chapter 16. Translational Research Involving Adolescent Substance Abuse341
- Introduction343
- Ten Barriers to Translation of Research Findings Involving Adolescent Suds344
- Examples of Immediate Implications of Prevention, Assessment, or Treatment Developments Involving Ad347
- Future Directions for Translational Research Involving Adolescent Suds351
- Acknowledgments356
- References356
- Section IV: Practice and Policy361
- Chapter 17. Dissemination of Evidence-Based Treatment into Substance Abuse Clinical Practice363
- Introduction364
- Critical Review of Research Literature364
- Immediate Implications369
- Conclusion375
- Acknowledgments376
- References376
- Chapter 18. Alcohol Screening and Intervention in Medical and Surgical Settings379
- Current State of the Science379
- Current Implications for Detection and Treatment387
- Directions for Future Translational Research389
- References392
- Chapter 19. Internet-Based Interventions for Alcohol, Tobacco and Other Substances of Abuse399
- Introduction400
- What do Internet-Based Interventions for Alcohol,Tobacco and other Drug Concerns Look Like?400
- Why Bother? Who uses the Internet and why won’t they Show up in Treatment?406
- What is the Evidence that Internet-Based Interventions Work?407
- Future Directions – What questions need answering and What might IBIs for substance abuse look lik412
- Acknowledgments and Conflict-of-Interest Statement413
- References413
- Chapter 20. Alcohol Use Among Undergraduate Students: From Brief Interventions to Behavioral Economi417
- Undergraduate Student Drinking: From Brief Interventions to Behavioral Economics418
- Alcohol use among undergraduate students418
- The use of brief Interventions to Reduce College Student Drinking423
- The Behavioral Economic Perspective427
- Final thoughts on Brief Interventions and Behavioral Economics431
- References433
- Chapter 21. Ethical and Policy Issues in the Translation of Genetic and Neuroscience Research on Add439
- Introduction440
- Theories of Addiction: Skeptical views and Medical Models441
- Practical Applications of Genetic and Neuroscience Research444
- Epistemic Implications of Genetic and Neuroscientific Knowledge450
- Future Directions for Addiction Policy452
- References453
- Section V: Conclusion459
- Chapter 22. Pathways to Innovation in Addiction Practice461
- Processes of Translation from Basic Science to Practice462
- An Alternate Pathway to Improved Practice466
- A Way Forward468
- References469
- Subject Index473
Recent advances in the understanding of the genetic, neurochemical, behavioral and cultural underpinnings of addiction have led to rapid advances in the understanding of addiction as a disease. In fact, advances in basic science and the development of new pharmacological and behavioral therapies associated with them are appearing faster than can be assimilated not only by clinical researchers but practitioners and policy makers as well. Translation of science-based addictions knowledge into improved prevention, assessment and treatment, and communication of these changes to researchers and practitioners are significant challenges to the field.
The general aim of this book is to summarize current and potential linkages between advances in addiction science and innovations in clinical practice. Whilst this book is primarily focused on translation, it also encompasses some scientific advances that are relevant to dissemination, and the book is itself a tool for disseminating innovative thinking.
The goal is to generate interest in application opportunities from both recent research and theoretical advances.
*Provides a much needed resource for translating current research into clinical practice
*Focuses upon alcohol, tobacco, and substance abuse addictions
*Addresses method of research and best dissemination techniques
The general aim of this book is to summarize current and potential linkages between advances in addiction science and innovations in clinical practice. Whilst this book is primarily focused on translation, it also encompasses some scientific advances that are relevant to dissemination, and the book is itself a tool for disseminating innovative thinking.
The goal is to generate interest in application opportunities from both recent research and theoretical advances.
*Provides a much needed resource for translating current research into clinical practice
*Focuses upon alcohol, tobacco, and substance abuse addictions
*Addresses method of research and best dissemination techniques