Elsevier S & T

Treatment of the Postmenopausal Woman: Basic and Clinical Aspects

Lobo, Rogerio A.

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Table of contents

Contentsxi
Contributorsv
Prefaceix
Chapter 1. The Menopause: A Signal for the Future1
Section I: Basics to Enhance Our Understanding15
Chapter 2. Molecular Pharmacology of Estrogen and Progesterone Receptors17
Chapter 3. Genetic Programming in Ovarian Development and Oogenesis29
Chapter 4. Basic Biology: Ovarian Anatomy and Physiology49
Chapter 5. Endocrine Changes During the Perimenopause67
Chapter 6. Epidemiology of Menopause: Demographics, Environmental Influences, and Ethnic and Interna77
Section II: Ovarian Senescence and Options97
Chapter 7. Premature Ovarian Failure99
Chapter 8. Reproductive Options for Perimenopausal and Menopausal Women111
Section III: The Perimenopause125
Chapter 9. Neuroendocrine Regulation of the Perimenopause Transition127
Chapter 10. Changes in the Menstrual Pattern During the Menopause Transition149
Chapter 11. Decisions Regarding Treatment During the Menopause Transition157
Chapter 12. Use of Contraceptives for Older Women169
Section IV: Changes Occurring After Menopause185
Chapter 13. Menopausal Hot Flashes187
Chapter 14. Clinical Effects of Sex Steroids on the Brain199
Chapter 15. Impact of the Changing Hormonal Milieu on Psychological Functioning217
Chapter 16. Connective Tissue Changes in the Menopause and with Hormone Replacement Therapy227
Chapter 17. Menopause and the Skin237
Chapter 18. Urogenital Symptoms around the Menopause and Beyond251
Chapter 19. Vulvovaginal Complaints263
Chapter 20. Sexuality: Clinical Implications from Epidemiologic Studies271
Section V: Brain Function277
Chapter 21. Menopause and Cognition279
Chapter 22. Cognitive Health in the Postmenopausal Woman287
Chapter 23. The Role of Sex Steroids in Alzheimer's Disease: Prevention and Treatment295
Chapter 24. Estrogens and Depression in Women307
Section VI: Bone Changes321
Chapter 25. Pathogenesis of Osteoporosis323
Chapter 26. Assessment of Bone Density and Bone Strength331
Chapter 27. Biochemical Markers of Bone Turnover337
Chapter 28. Interventions for Osteoporosis351
Chapter 29. Treatment of Osteoporosis377
Chapter 30. Potentials of Estrogens in the Prevention of Osteoarthritis: What Do We Know and What Qu393
Section VII: Cardiovascular403
Chapter 31. Epidemiology and Risk Factors of Cardiovascular Disease in Postmenopausal Women405
Chapter 32. Mechanisms of Action of Estrogen on the Cardiovascular System453
Chapter 33. Lipids and Lipoproteins and Effects of Hormone Therapy461
Chapter 34. The Effects of Hormone Therapy on Inflammatory, Hemostatic, and Fibrinolytic Markers in471
Chapter 35. Hormone Therapy and Hemostasis481
Chapter 36. Risk of Pulmonary Embolism/Venous Thrombosis491
Chapter 37. Glucose Metabolism After Menopause501
Chapter 38. Stage of Reproductive Life, Atherosclerosis Progression and Estrogen Effects on Coronary509
Chapter 39. Randomized Controlled Trials and the Effects of Postmenopausal Hormone Therapy on Cardio529
Section VIII: Neoplasia565
Chapter 40. Body Weight, Menopausal Hormone Therapy, and Risk of Breast Cancer569
Chapter 41. Postmenopausal Breast Surveillance579
Chapter 42. Endometrial Cancer and Hormonal Replacement Therapy585
Chapter 43. Ovarian Cancer and Its Detection593
Chapter 44. Hormone Replacement Therapy in Menopause and Breast, Colorectal, and Lung Cancer: An Upd599
Section IX: Clinical Trials and Observational Data609
Chapter 45. The Women's Health Initiative~Data and Discussion611
Chapter 46. Postmenopausal Hormone Therapy in the 21st Century: Reconciling Findings from Observatio619
Chapter 47. Morbidity and Mortality Changes with Hormone Therapy627
Section X: Life Cycle and QOL637
Chapter 48. Issues Relating to Quality of Life in Postmenopausal Women and Their Measurement639
Chapter 49. Role of Exercise and Nutrition655
Chapter 50. Herbs, Phytoestrogens, and Other CAM Therapies683
Section XI: Urinary Symptoms and Pelvic Support691
Chapter 51. Lower Urinary Tract Disorders in Postmenopausal Women693
Chapter 52. Pelvic Organ Prolapse in Postmenopausal Women739
Section XII: Hormonal Therapy765
Chapter 53. Pharmacology of Estrogens767
Chapter 54. Structure-Function Relationships, Pharmacokinetics, and Potency of Orally and Parenteral779
Chapter 55. Intervention: Androgens799
Chapter 56. Future Strategies in Climacteric Medicine813
Section XIII: Some Alternative Medical Therapies819
Chapter 57. Alternative Therapy: Dehydroepiandrosterone for Menopausal Hormone Replacement821
Chapter 58. Melatonin829
Chapter 59. Selective Estrogen Receptor Modulators837
Chapter 60. Tibolone: Selective Tissue Estrogen Activity Regulator Utilization in Postmenopausal Wom847
Section XIV: Women's Centers, Information Needed for Clinical Trials, and the Future853
Chapter 61. Integrated Adult Women's Medicine: A Model for Women's Health Care Centers855
Chapter 62. Clinical Trials in Postmenopausal Hormone Therapy863
Chapter 63. The Future of Therapy and the Role of Hormone Therapy875
Subject Index881
Color Plate Section895

Book details

Vendor Elsevier S & T
SKU 9780123694430
ISBN-13 9780080553092
Author Lobo, Rogerio A.
Edition 3rd
Category Medical
Subject Endocrinology & Metabolism

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Ask an expert!

For anyone who treats postmenopausal women, this latest edition of Rogerio Lobo's classic work combines the best from two well-known references: Menopause, and the second edition of Treatment of the Postmenopausal Woman. By adding significant discussions of the basic science behind menopause, it is possible to objectively assess the clinical value and limitations of current approaches to treatment and provide a basis and rationale for strategies that will result in better individualized and specialized care. Not only does the third edition discuss diagnosis and treatment of menopause but it covers biological, anatomical, physiological, pathobiological, and pharmacological aspects as well bringing together, in one source, all of the information needed to understand and treat postmenopausal conditions.

* Over 50% new material representing the vast amount of information available since the Women's Health Initiative (WHI) clinical trials were completed making this the most up-to-date reference on postmenopausal women
* Includes several new sections on comparisons between clinical trials and observational data, urology, and pelvic support
* Each section is preceded by a preface to put the area into context with many chapters having suggested treatment regimens

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