Elsevier S & T

Trends in Drug Research III

van der Goot, H.

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Table of contents
  • Cover
  • Contentsvii
  • Prefaceix
  • Chapter 1. Towards rational design of AMPA receptor ligands: an integrated medicinal, computational,1
  • Chapter 2. From heparin to synthetic antithrombotics. The pentasaccharide story and follow-up13
  • Chapter 3. A new future for synthesis?21
  • Chapter 4. Directed evolution of enantioselective enzymes as catalysts in the production of chiral p27
  • Chapter 5. At the interface of organic synthesis and biosynthesis39
  • Chapter 6. What can structure tell us about function in the estrogen receptors?53
  • Chapter 7. Molecular docking and dynamics simulations in the ligand binding domain of steroid hormon57
  • Chapter 8. Peroxisome proliferator-activated receptors and reverse endocrinology67
  • Chapter 9. Biomolecular mass spectrometry related to drug research81
  • Chapter 10. Chemical and biological diversity in drug discovery95
  • Chapter 11. Muscarine acetylcholine receptor knockout mice: phenotypical analysis and clinical impli97
  • Chapter 12. Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful per115
  • Chapter 13. Computational methods for the analysis of molecular diversity125
  • Chapter 14. Enhancing drug discovery by acquisition of chemical diversity135
  • Chapter 15. Chemical diversity as a driving force to design and put in practice synthetic strategies147
  • Chapter 16. Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signalli161
  • Chapter 17. Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D2 dopam175
  • Chapter 18. Agonist channeling of α2-adrenoceptor function181
  • Chapter 19. Antibacterials as wonder drugs and how their effectiveness is being compromised193
  • Chapter 20. Pseudomonas aeruginosa quorum sensing: a target for antipathogenic drug discovery207
  • Chapter 21. Discovery and development of new anti-bacterial drugs213
  • Chapter 22. Discovery of small molecule insulin mimetics as potential novel antidiabetic agents227
  • Chapter 23. Expression databases for pharmaceutical lead optimisation237
  • Chapter 24. New developments in the pharmacology of cannabinoids249
  • Author index259
  • Subject index261
Book details
  • Vendor Elsevier S & T
  • SKU 9780444507600
  • ISBN-13 9780080543239
  • Author van der Goot, H.
  • Category Medical
  • Subject Pharmacology

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The tradition of setting new trends in medicinal chemistry continued at the 13th Symposium where topics included chemical and biological diversity, new paradigms in drug action, and new insights in receptor mechanisms. Other topics of great interest discussed, and included in these proceedings, are the discoveries in green chemistry, the interface between organic synthesis and biosynthesis, the growing problem of resistant micro-organisms and the possibilities to identify new, and better, antibiotics. And finally, in recent developments, the discovery of small molecules with insulin sensitizing properties.