Vitamins and Hormones
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Table of contents
- Cover
- Contentsvii
- Prefacexi
- Chapter 1. Ecdysone Receptors and Their Biological Actions1
- I. Introduction1
- II. Nomenclature5
- III. EcR and USP Isoforms7
- IV. The Ecdysone Receptor7
- V. Biological Actions23
- VI. Regulation of EcR and USP48
- VII. Evolution of EcR and USP in the Arthropoda52
- VIII. Concluding Observations57
- References59
- Chapter 2. Chromatin-Remodeling Complexes Involved in Gene Activation by the Glucocorticoid Receptor75
- I. Introduction76
- II. The GR Belongs to the Nuclear Receptor Superfamily76
- III. Biological Effects of Glucocorticoids77
- IV. Functional Domains of the Glucocorticoid Receptor79
- V. Mechanisms of Glucocorticoid Receptor Action83
- VI. General Mechanisms of Gene Activation86
- VII. Chromatin91
- VIII. ATP-Dependent Chromatin Remodeling93
- IX. Histone Acetylation96
- X. Histone Deacetylation102
- XI. Diseases Linked to Chromatin103
- XII. Concluding Remarks106
- References107
- Chapter 3. Mechanism of Action of Estrogens and Selective Estrogen Receptor Modulators123
- I. Introduction124
- II. Estrogen124
- III. Selective Estrogen Receptor Modulators135
- IV. Phytoestrogens138
- V. Conclusion140
- References141
- Chapter 4. The Role of Protein Kinase C in the Development of the Complications of Diabetes149
- I. General Introduction150
- II. PKC Biochemistry and Pharmacology151
- III. Diabetic Retinopathy155
- IV. Diabetic Nephropathy160
- V. Neuropathy165
- VI. Atherosclerosis171
- References177
- Chapter 5. Transcriptional Regulation of the LHβ Gene by Gonadotropin-Releasing Hormone and the Pro195
- I. Introduction195
- II. GnRH Signaling and Gonadotropin Biosynthesis197
- III. Model Systems Used in Analysis of the LHβ Gene Promoter201
- IV. Initial Characterization of the LHβ Gene 5' Flanking Region202
- V. Early Growth Response Protein 1 (Egr-1) and LHβ Gene Expression204
- VI. Steroidogenic Factor-1 (SF-1) and the LHβ Gene209
- VII. Sp1 and LHβ Gene Expression215
- VIII. DAX-1 and the GnRH Response217
- IX. Pituitary Homeobox 1 (Ptx1) and LHβ Gene Expression218
- X. Conclusions219
- References220
- Chapter 6. Angiotensin II and Calcium Channels229
- I. Introduction230
- II. Angiotensin II Receptor Subtypes and Mode of Action231
- III. Electrophysiological Properties and Molecular Biology of the Various Types of Calcium Channels239
- IV. Molecular Mechanisms of Angiotensin II-Induced Modulation of Calcium Channels247
- V. Conclusion268
- References268
- Chapter 7. Liposome Targeting to Tumors using Vitamin and Growth Factor Receptors285
- I. Introduction286
- II. Targeting of Liposomes to Vitamin Receptors: The Case of Folic Acid294
- III. Targeting Liposomes to Growth Factor Receptors307
- IV. Conclusions and Future Perspectives320
- References321
- Chapter 8. Vitamins and Homocysteine Metabolism333
- I. Introduction333
- II. Homocysteine Metabolism334
- III. Homocysteine and Health340
- IV. Vitamin Status and Plasma Homocysteine345
- V. Conclusion348
- References348
- Chapter 9. Cobalamins and Folates as Seen through Inborn Errors of Metabolism: A Review and Perspect353
- I. Introduction353
- II. Background Review354
- III. Techniques and Critique363
- IV. Inborn Errors of Metabolism366
- V. Evolving Concepts and Conclusions374
- References375
- Index383
Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.
This volume comprises three groups of contributors. The first three papers deal with receptors and their actions. The second group of three papers are on diabetes and specific hormones. The last three papers are presentations on various aspects of vitamins and growth factors.
This volume comprises three groups of contributors. The first three papers deal with receptors and their actions. The second group of three papers are on diabetes and specific hormones. The last three papers are presentations on various aspects of vitamins and growth factors.