Vitamins and Hormones
Regular price
79.500 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Contentsvii
- Prefacexi
- Chapter 1. Green Tea: Biochemical and Biological Basis for Health Benefits1
- I. Introduction2
- II. Catechins and Other Constituents of Green Tea4
- III. Structure, Pharmacology, and Metabolism of Catechins5
- IV. Chemical and Biochemical Properties of Catechins9
- V. Biological Activity of Green Tea Catechins14
- VI. Molecular and Cellular Bases for Biological Effects of Catechins52
- VII. Epilog69
- References71
- Chapter 2. Proteins Regulating the Biosynthesis and Inactivation of Neuromodulatory Fatty Acid Amide95
- I. Fatty Acid Amides as Endogenous Signaling Molecules95
- II. The Biosynthesis of Fatty Acid Amides98
- III. The Enzymatic Inactivation of Fatty Acid Amides104
- IV. Transport of Fatty Acid Amides116
- V. Conclusions and Future Challenges121
- References123
- Chapter 3. Three-Dimensional Organization of the Aquaporin Water Channel: What Can Structure Tell Us133
- I. Movement of Water across the Membrane„Discovery of Aquaporin-1133
- II. Mammalian Aquaporins and Their Transport Function134
- III. Investigations of Amino Acid Residues Involved in Solute Transport in Aquaporins137
- IV. Structural Studies of Aquaporins138
- V. Unresolved Questions and Future Directions158
- References160
- Chapter 4. Cytostatic p21 G Protein-Activated Protein Kinase γ-PAK167
- I. Background168
- II. Comparison of PAK Proteins170
- III. Autophosphorylation and Activation of γ-PAK173
- IV. γ-PAK Has Cytostatic Activity174
- V. Activation of γ-PAK in Response to Stress177
- VI. The Individual Roles of γ-PAK and SAPK/p38 in the Stress Response185
- VII. Substrates for γ-PAK186
- VIII. Working Model—A Role for γ-PAK as a Master Switch189
- IX. Conclusions and Remaining Questions191
- References192
- Chapter 5. Androgen Receptors and Their Biology199
- I. Mechanism of Androgen Action199
- II. Sexual Development204
- III. Androgen Receptors and Disease207
- IV. Androgen Action and Other Diseases213
- V. Conclusion219
- References219
- Chapter 6. Transcriptional Activation of Genes by 17β-Estradiol through Estrogen Receptor–Sp1 Int231
- I. Introduction232
- II. Transcriptional Activation through Sp1(N)xERE 1/2 and Sp1(N)xERE Motifs234
- III. Transcriptional Activation by E2 through GC-Rich Sites237
- IV. E2-Responsive Genes with Functional GC-Rich Promoter Elements239
- V. ERα/Sp1 Activation by Growth Factors242
- VI. ERα/Sp1 vs ERβ/Sp1 Action and Effects of Ligand Structure and Cell Context243
- VII. Summary244
- References245
- Chapter 7. Drug Discovery and the Intracellular Receptor Family253
- I. The History of Intracellular Receptor Ligands as Drugs254
- II. Diseases in Which Intracellular Receptors Play a Role254
- III. Intracellular Receptor Ligands with Therapeutic Utility (Agonists and Antagonists)255
- IV. Partial Agonists of Intracellular Receptors257
- V. Ligand Discovery260
- VI. Direct Measures of Intracellular Receptor Conformation266
- VII. Indirect Methods of Conformation Determination267
- VIII. Cofactor–Receptor Interactions268
- IX. Assays Used to Measure the Function of the Ligand–Receptor Complex270
- X. The in Vitro–in Vivo Connection272
- XI. Conclusion274
- References274
- Index281
Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Every volume contains comprehensive reviews by leading contributors.