Vitamins and Hormones
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Table of contents
- Contentsvii
- Prefacexi
- Chapter 1. Fertilization Promoting Peptide„A Possible Regulator of Sperm Function in Vivo1
- I. Introduction2
- II. Fertilization Promoting Peptide3
- III. Fertilization Promoting Peptide Receptor10
- IV. Mechanism of Action of Fertilization Promoting Peptide12
- V. Other Seminal Plasma Peptides17
- VI. Discussion20
- References24
- Chapter 2. Cytokines and Pituitary Hormone Secretion29
- I. Introduction29
- II. Cytokines in the Brain31
- III. IL Receptors in the Brain32
- IV. The Role of Nitric Oxide in Control of Hypothalamic–Pituitary Function33
- V. The Role of the Hypothalamic–Pituitary System in Infection35
- VI. The Effect of Cytokines and Nitric Oxide on the Release of Corticotropin-Releasing Hormone38
- VII. The NOergic Control of Luteinizing Hormone-Releasing Hormone Release41
- VIII. The Effect of Cytokines (IL-1 and Granulocyte Macrophage Colony-Stimulating Factor) on the NOe45
- IX. The Role of Nitric Oxide in Mating Behavior46
- X. The Effect of Cytokines and Nitric Oxide on the Release of Other Hypothalamic Peptides47
- XI. The Action of Cytokines and Nitric Oxide to Control Release of Anterior Pituitary Hormones48
- XII. The Adipocyte Hormone Leptin50
- XIII. The Control of Cytokine Release53
- XIV. Concluding Remarks55
- References56
- Chapter 3. Mechanism of GnRH Receptor Signaling on Gonadotropin Release and Gene Expression in Pitui63
- I. Introduction64
- II. GnRH Receptor: Structure–Function Studies65
- III. Phosphoinositide Turnover and Sequential Activation of Phospholipases71
- IV. Role of Calcium in GnRH Action73
- V. Role of Protein Kinase C74
- VI. Role of Mitogen-Activated Protein Kinase76
- VII. Role of Arachidonic Acid79
- VIII. Integration of Signaling Molecules80
- IX. The Pituitary as an Independent Endogenous Oscillator80
- References82
- Chapter 4. Luteinizing Hormone-Releasing Hormone (LHRH) Neurons: Mechanism of Pulsatile LHRH Release91
- I. Introduction92
- II. Physiology and Anatomy of LHRH Neurons92
- III. Models for Studying Pulsatile Release of LHRH95
- IV. Cellular and Molecular Mechanisms of LHRH Pulse Generation97
- V. Intercellular Signals102
- VI. Steroid Hormones114
- VII. Mathematical Models114
- References115
- Chapter 5. LH Pulses and the Corpus Luteum: The Luteal Phase Deficiency (LPD)131
- I. Introduction132
- II. The Short Luteal Phase as a Cause of Infertility132
- III. Serum Progesterone Levels in Infertile Subjects133
- IV. What Is NormalŽ?135
- V. Treatment of Luteal Phase Deficiencies154
- References154
- Chapter 6. Granulocyte Colony-Stimulating Factor Receptor: Structure and Function159
- I. Introduction159
- II. Gene Structure and Expression of G-CSF-R160
- III. Structure–Function of G-CSF-R163
- IV. G-CSF and Its Biological Roles166
- V. G-CSF-R Signal Transduction168
- VI. Neutrophil Differentiation: A Model176
- VII. G-CSF-R Mutation in Human Disease178
- VIII. Clinical Use of G-CSF179
- IX. Concluding Remarks181
- References181
- Chapter 7. The Physiological Role of Melanocortin Receptors195
- I. Introduction195
- II. The Melanocortin Receptors197
- III. The Melanocortic Peptides and Useful Ligands202
- IV. Pigmentation207
- V. Inflammation208
- VI. Food Intake210
- VII. Cardiovascular Effects215
- VIII. Sexual Function217
- IX. Other Functions219
- X. Concluding Remarks221
- References222
- Chapter 8. The Growth Hormone-Releasing Hormone Receptor233
- I. Introduction233
- II. Growth Hormone-Releasing Hormone234
- III. Isolation of the Growth Hormone-Releasing Hormone Receptor236
- IV. Structural Features of the Growth Hormone-Releasing Hormone Receptor236
- V. Hormone Binding and Cellular Signaling by the Growth Hormone-Releasing Hormone Receptor237
- VI. Growth Hormone-Releasing Hormone Receptor Gene Structure239
- VII. Growth Hormone-Releasing Hormone Receptor Expression and Regulation244
- VIII. Isoforms and Variants of the Growth Hormone-Releasing Hormone Receptor248
- IX. Interaction between the Growth Hormone-Releasing Hormone Receptor and Its Ligand252
- X. Growth Hormone-Releasing Hormone Receptor in Diseases of the Growth Hormone Axis255
- XI. Summary and Perspectives260
- References265
- Index277
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Key Features
* Reviews on the most current topics in the field, including:
* Fertilization promoting peptide--a possible regulator of sperm function in vivo
* Cytokines and pituitary hormone secretion
* Mechanism of GnRH receptor signaling upon gonadotropin release and gene expression in pituitary gonadotrophs
* Luteinizing-hormone releasing hormone (LHRH) neurons
* LH pulses and the corpus luteum
* Granulocyte colony-stimulating factor receptor
* The physiological role of the melancortin receptors
* The growth hormone-releasing hormone receptor
Key Features
* Reviews on the most current topics in the field, including:
* Fertilization promoting peptide--a possible regulator of sperm function in vivo
* Cytokines and pituitary hormone secretion
* Mechanism of GnRH receptor signaling upon gonadotropin release and gene expression in pituitary gonadotrophs
* Luteinizing-hormone releasing hormone (LHRH) neurons
* LH pulses and the corpus luteum
* Granulocyte colony-stimulating factor receptor
* The physiological role of the melancortin receptors
* The growth hormone-releasing hormone receptor