Vitamins and Hormones
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Table of contents
- Contentsvii
- Prefacexi
- Chapter 1. Embryonic Stem Cells Provide a Powerful and Versatile Model System1
- I. Introduction2
- II. Characteristics of ES Cells and Their Close Relatives, EC Cells and EG Cells3
- III. Isolation and Cultivation of ES Cells and EG Cells6
- IV. In Vitro Differentiation of ES Cells11
- V. ES and EC Cells: Powerful Model Systems for Studying Gene Expression20
- VI. Future Perspectives28
- References33
- Chapter 2. Molecules in Blastocyst Implantation: Uterine and Embryonic Perspectives43
- I. Introduction44
- II. Embryo–Uterine Interactions46
- III. Uterine Factors in Implantation51
- IV. Embryonic Factors in Implantation60
- V. Uterine Markers in Humans65
- VI. Conclusion66
- References68
- Chapter 3. Microarray Analysis of B-Cell Stimulation77
- I. Introduction78
- II. Materials and Methods79
- III. Results and Discussion81
- IV. Conclusions94
- References94
- Chapter 4. Tissue Culture Models for Studies of Hormone and Vitamin Action in Bone Cells101
- I. Introduction102
- II. The Skeleton103
- III. Bone Remodeling103
- IV. Hormonal Regulation of Bone Remodeling105
- V. Osteoclast Biology109
- VI. Tissue Culture Models for the Study of Osteoclasts110
- VII. Osteoblast Biology117
- VIII. Tissue Culture Models for the Study of Osteoblasts119
- IX. Closing Remarks140
- References140
- Chapter 5. Transport of Leukotriene C4 and Structurally Related Conjugates153
- I. Introduction154
- II. ATP-Dependent Biosynthetic Release of Leukotriene C4155
- III. Hepatobiliary Elimination of Cysteinyl Leukotrienes170
- IV. Conclusions174
- References175
- Chapter 6. Interleukin-1β Exerts a Myriad of Effects in the Brain and in Particular in the Hippocam185
- I. Introduction186
- II. The IL-1 Superfamily and Associated Receptors186
- III. IL-1 and the CNS189
- IV. Effect of IL-1β in the Hippocampus195
- V. What Mediators Are Utilized by IL-1β?208
- VI. Conclusions208
- References209
- Chapter 7. Leptin and Sweet Taste221
- I. Introduction222
- II. Genetic Approaches to Taste Receptor Mechanisms224
- III. Sweet Taste Responses in db/db Mice226
- IV. Leptin as a Modulator of Sweet Taste Responses228
- V. Intracellular Mechanisms for Leptin Modulation of Sweet Taste Responses232
- VI. Leptin Effects on Regulation of Food Intake through Modulation of Sweet Sensitivities236
- VII. Conclusion241
- References242
- Chapter 8. Molecular, Structural, and Cellular Biology of Follitropin and Follitropin Receptor249
- I. Background and Nomenclature250
- II. Molecular Genetics of Human Follitropin251
- III. Regulation of Follitropin Protein Levels253
- IV. General Features of Follitropin Deduced from cDNA257
- V. Structural Biology of Follitropin263
- VI. Molecular Genetics of Follitropin Receptor268
- VII. General Features of Follitropin Receptor Deduced from cDNA277
- VIII. Follitropin Receptor Structure and Function Correlates284
- IX. Follitropin Receptor Signal Transduction291
- X. Summary and Conclusions301
- References302
- Chapter 9. Factor VIIa/Tissue Factor-Induced Signaling: A Link between Clotting and Disease323
- I. Coagulation System324
- II. Nonhemostatic Functions of Tissue Factor and Factor VIIa325
- III. Potential Mechanisms by Which VIIa/Tissue Factor Regulates Biological Functions331
- IV. Physiological Significance of VIIa/Tissue Factor-Induced Signaling346
- V. Summary350
- References350
- Chapter 10. Antiproliferative Action of Vitamin D357
- I. Introduction358
- II. The General Mechanism of Vitamin D Action359
- III. Antiproliferative Effects of Vitamin D on Cell Growth366
- IV. The Role of Vitamin D Crosstalk in Growth Factor and Hormone Signaling376
- V. Vitamin D and Cancer382
- VI. Conclusions and Future Perspectives387
- References388
- Index407
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Vitamins are organic substances not naturally produced by the body that are necessary in trace amounts for normal physiologic and metabolic functioning. Hormones are biochemical substances produced in cells and tissues that cause a specific biological change or activity to occur elsewhere in the body.
Study of both vitamins and hormones is essential to our understanding of physiology.
This volume of Vitamins and Hormones,/b> contains articles on: Embryonic Stem Cells; Molecules in Blastocyst Implantation; Microarray Analysis of B Cell Stimulation; Tissue Culture Models for Studies of Hormone and Vitamin Action in Bone Cells; Transport of Leukotriene C4 and Structurally Related Conjugates; IL-1 beta Exerts a Myriad of Effects in the Brain; Leptin and Sweet Taste; Molecular, Structural and Cellular Biology of Follitropin and Follitropin Receptor; Factor VIIa/Tissue Factor-Induced Signaling; and Antiproliferative Action of Vitamin D. Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Every volume contains comprehensive reviews by leading contributors.
Vitamins are organic substances not naturally produced by the body that are necessary in trace amounts for normal physiologic and metabolic functioning. Hormones are biochemical substances produced in cells and tissues that cause a specific biological change or activity to occur elsewhere in the body.
Study of both vitamins and hormones is essential to our understanding of physiology.
This volume of Vitamins and Hormones,/b> contains articles on: Embryonic Stem Cells; Molecules in Blastocyst Implantation; Microarray Analysis of B Cell Stimulation; Tissue Culture Models for Studies of Hormone and Vitamin Action in Bone Cells; Transport of Leukotriene C4 and Structurally Related Conjugates; IL-1 beta Exerts a Myriad of Effects in the Brain; Leptin and Sweet Taste; Molecular, Structural and Cellular Biology of Follitropin and Follitropin Receptor; Factor VIIa/Tissue Factor-Induced Signaling; and Antiproliferative Action of Vitamin D. Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Every volume contains comprehensive reviews by leading contributors.