Vitamins and Hormones
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Table of contents
- Cover
- Copyright Pageiv
- Contentsvii
- Contributorsxv
- Prefacexix
- Chapter 1. Molecular Biology of Hematopoietic Stem Cells1
- I. Introduction2
- II. Immunological and Functional Characteristics3
- III. Cell Cycle and Differentiation Control6
- IV. Adhesion Molecules in Hematopoiesis and Stem Cell Trafficking10
- V. Aging and Telomeres13
- VI. Trandifferentiation and Developmental Plasticity17
- VII. Conclusions19
- References19
- Chapter 2. Aldosterone: Its Receptor, Target Genes, and Actions29
- I. Introduction30
- II. Physiological Actions of Aldosterone32
- III. Molecular Basis of Mineralocorticoid Action37
- IV. Aldosterone Action in Epithelia: Afforded by 11B-Hydroxysteroid Dehydrogenase 242
- V. Genetic Mouse Models in the Investigation of Aldosterone Action46
- VI. Aldosterone Target Genes That Mediate Physiological Responses48
- VII. Controversies with Aldosterone57
- VIII. Concluding Remarks61
- References62
- Chapter 3. Corticosteroid Receptors, 11B-Hydroxysteroid Dehydrogenase, and the Heart77
- I. Introduction79
- II. Corticosteroid Hormones79
- III. Corticosteroid Receptors80
- IV. Mechanism of Action of Corticosteroid Receptor84
- V. Modulators of Corticosteroid Signaling87
- VI. Heart91
- VII. Summary101
- References102
- Chapter 4. Forms of Mineralocorticoid Hypertension113
- I. Introduction114
- II. Evolution, Salt, and the Renin-Angiotensin-Aldosterone System115
- III. Key Elements of Mineralocorticoid Activity117
- IV. Mineralocorticoid Hypertension124
- V. Primary Aldosteronism125
- VI. Genetic Forms of Mineralocorticoid Hypertension135
- VII. Aldosterone–Dependent Essential Hypertension142
- References143
- Chapter 5. Peroxisome Proliferator-Activated Receptors and the Cardiovascular System157
- I. Introduction158
- II. Discovery, Structure, and Tissue Distribution of PPARs,159
- III. PPARs Ligands160
- IV. Mechanisms of Action of PPARs162
- V. PPARy in the Cardiovascular System163
- VI. PPARa in the Cardiovascular System170
- VII. PPARd in the Cardiovascular System173
- VIII. Conclusions175
- References176
- Chapter 6. Serotonin and the Neuroendocrine Regulation of the Hypothalamic-Pituitary- Adrenal Axis i189
- I. Overview of Serotonin190
- II. Neuroanatomy of the Hypothalamic-Pituitary-Adrenal Axis195
- III. Serotonin and the Hypothalamic-Pituitary-Adrenal Axis203
- IV. Physiological Interactions212
- V. Pathophysiological Interactions220
- VI. Concluding Remarks228
- References229
- Chapter 7. The Thymosins: Prothymosin a, Parathymosin, and B-Thymosin: Structure and Function257
- I. Introduction258
- II. Polypeptide B1259
- III. a-Thymosins and Prothymosin a260
- IV. Parathymosin270
- V. B -Thymosins273
- VI. Conclusions284
- References285
- Chapter 8. Thymosin B4 Interactions297
- I. B-Thymosin Structure298
- II. Thymosin B4 and the Actin Cytoskeleton299
- III. Assays for Thymosin B4-Actin Interactions306
- IV. Ternary Complexes309
- V. Thymosin B4 Ligands in Immunity and Inflammation312
- Chapter 9. Polypeptide Hormones: Signaling Molecules in Plants317
- I. Introduction318
- II. Systemin and Systemin-like Peptides318
- III. Rapid Alkalinization Factor (RALF)321
- IV. ENOD40 and Root Nodulation322
- V. CLAVATA3 and Meristem Organization324
- VI. Phytosulfokines327
- VII. Brassica Self-Incompatibility330
- VIII. Polaris (PLS)334
- IX. Conclusion337
- References337
- Chapter 10. Parathyroid Hormone-Related Protein (PTHrP): A Nucleocytoplasmic Shuttling Protein with345
- I. Introduction346
- II. Paracrine and Intracrine Actions of PTHrP347
- III. The Nuclear Import Mechanism of PTHrP356
- IV. Nuclear Transport of Polypeptide Ligands368
- V. Nuclear Export Pathway of PTHrP370
- VI. Functional Role of PTHrP in the Nucleus/Nucleolus372
- VII. Future Prospects374
- References375
- Chapter 11. Nerve Growth Factor-Dependent Regulation of Nade-Induced Apoptosis385
- I. Background386
- II. Structural Features of NADE389
- III. NADE Isoforms390
- IV. Genomic Structure of NADE Genes391
- V. Expression of NADE392
- VI. Association of NADE with P75NTR393
- VII. 14-3-3 Protein Interacts with NADE395
- VIII. NADE Is Involved in NGF-Induces Apoptosis via P75NTR395
- IX. Future Directions398
- References399
- Chapter 12. Membrane Transport of Folates403
- I. Introduction405
- II. Reduced Folate Carrier (RFC), a Member of the SLC19 Family of Transporters405
- III. Transport of Folates by SLC21 Organic Anion Carriers427
- IV. Folate Transporters That Operate Optimally at Low pH: The Mechanism of Folate Transport in Intes428
- V. The Family of Folate Receptors (FRs)430
- VI. Multidrug Resistance-Associated Proteins (MRPs) and Their Impact on the Transport of Folates434
- VII. Transport of Folates by Other ABC Exporters436
- VIII. Factors That Influence Concentrative Folate Transport in Cells437
- IX. The Localization of Folate Transport in Epithelia439
- X. The Role if Folate Transporters in Mouse Development441
- References441
- Chapter 13. Vitamin A and Infancy: Biochemical, Functional, and Clinical Aspects457
- I. A Premise458
- II. Vitamin A: Intestinal Digestion, Absorption, and Tissue Delivery459
- III. Intracellular Metabolism464
- IV. Retinol and Embryogenesis: Mechanism of Action and Importance470
- V. Retinol and Infancy499
- VI. Altered Vitamin A Levels and Childhood Pathologies509
- VII. Few Final Considerations535
- References536
- Index593
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Key Features
* First published in 1943, Vitamins and Hormones is AP's longest running serial
* Each volume contains cutting edge reviews by leading contributors
Key Features
* First published in 1943, Vitamins and Hormones is AP's longest running serial
* Each volume contains cutting edge reviews by leading contributors