Vitamins and Hormones
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Table of contents
- Cover
- Contentsvii
- Contributorsxv
- Prefacexix
- Chapter 1. Reinterpretation of Basal Glucocorticoid Feedback: Implications to Behavioral and Metabo1
- I. Glucocorticoid Hormones and a New Hypothesis of Glucocorticoid Feedback2
- II. Basal Glucocorticoid Feedback4
- III. What Do Studies Using MR and GR Antagonists Tell Us about Glucocorticoid Feedback?7
- IV. CNS Lesion Studies and Presumed Sites of Glucocorticoid Feedback9
- V. Brain Exposure to Glucocorticoids: Feedback Sites Revealed?10
- VI. Acute Stress and Glucocorticoid Feedback11
- VII. Chronic Stress, the HPA Axis, and Energy Balance. Glucocorticoids Feed Back to Stimulate CRF Pa11
- VIII. Glucocorticoids, the HPA Axis, and Energy Balance13
- IX. Feeding Restores Energy Balance and Blunts HPA, CRF, and Behavioral Responses to Stress15
- X. Reinterpretation of Basal Glucocorticoid Feedback. A Glucocorticoid–Metabolic–Brain Feedback18
- XI. Implications of the Glucocorticoid–Metabolic–Brain Feedback Axis20
- References23
- Chapter 2. Activation of the Ligand–Mineralocorticoid Receptor Functional Unit by Ancient, Classi31
- I. Introduction32
- II. The Nuclear Receptor Superfamily34
- III. Steroid Receptors36
- IV. The Mineralocorticoid Effect37
- V. Structure–Activity Relationship for the Mineralocorticoid Effect40
- VI. Limitations of the Model45
- VII. Progesterone and Progesterone Derivatives46
- VIII. Extra-Adrenal Mineralocorticoid Agonists49
- IX. A Novel Synthetic Mineralocorticoid„11,19-Oxidoprogesterone50
- X. Ligand-Dependent Cytoplasmic Trafficking of the MR52
- XI. Redox Milieu Regulates Ligand Binding to the MR and Receptor Bioavailability56
- XII. Envoy58
- References62
- Chapter 3. Reciprocal Regulation and Integration of Signaling by Intracellular Calcium and Cyclic G69
- I. Introduction70
- II. Regulation of [Ca 2+]i by cGMP70
- III. Regulation of [cGMP]i by Ca2+74
- IV. Cyclic GMP–Calcium Signaling and Cellular Physiology79
- V. Conclusions87
- References88
- Chapter 4. Unusual Guanylyl Cyclases and cGMP Signaling in Dictyostelium Discoideum95
- I. Introduction96
- II. cGMP Targets97
- III. cGMP Phosphodiesterases99
- IV. Guanylyl Cyclases100
- V. Desensitization of cGMP Response107
- VI. Translocation of sGC to the Membrane109
- VII. Phylogeny of the cGMP Pathway110
- VIII. Conclusions and Future Perspectives111
- References111
- Chapter 5. CRH, Stress and Major Depression: A Psychobiological Interplay117
- I. Major Depression: Clinical Characteristics and Etiology119
- II. CRH, the HPA Axis, and Stress121
- III. Major Depression and the HPA Axis124
- IV. HPA Axis, MDD, and Genetics132
- V. Early Trauma and HPA Axis Development140
- VI. Conclusion142
- References143
- Chapter 6. Gonadotropin-Releasing Hormone Receptors: Structure, Expression, and Signaling Transducti151
- I. Introduction152
- II. GnRH Receptors Belong to the Family of G-Protein-Coupled Receptors153
- III. GnRH Receptors Possess Unique Features156
- IV. GnRH Receptor is Expressed in Extrapituitary Tissues and Various Tumors159
- V. Multiple Transcripts of GnRH Receptor are Present in Human Pituitary and Tumors160
- VI. GnRH Analogues Suppress Tumor Growth161
- VII. Structure of the GnRH Receptor163
- VIII. Nonmammalian GnRH Receptors Differ from Mammalian GnRH Receptors167
- IX. Mammalian GnRH-II Receptor (Type II Receptor) Contains C-Terminal Domain168
- X. GnRH-II Stimulates FSH and LH Secretion by Activating GnRH-I Receptors171
- XI. GnRH Receptor Mutations in Patients with Hypogonadotropic Hypogonadism172
- XII. GnRH Mediates its Functions through Multiple Signaling Pathways174
- XIII. GnRH Regulates Expression of a Large Number of Downstream Signaling Genes179
- References191
- Chapter 7. Familial Growth Hormone Deficiency and Mutations in the GHRH Receptor Gene209
- I. Introduction210
- II. The GHRH Receptor and its Gene212
- III. Mutations in the GHRHR Gene213
- IV. Clinical, Hormonal, and Radiological Phenotype of Patients with Bi-Allelic GHRHR Mutations215
- V. Hormonal and Radiological Phenotype of Heterozygous Carriers217
- VI. Conclusions217
- References218
- Chapter 8. The Roles of Phospholipase C-γ1 and Actin-Binding Protein Filamin A in Signal Transducti221
- I. Introduction222
- II. Insulin Receptor Sequence and Structure Analysis222
- III. PLCγ1 and Insulin Signaling229
- IV. Filamin A and Insulin Signaling235
- V. Conclusions240
- References241
- Chapter 9. Regulation of Expression of the NA+/H+ Exchanger by Thyroid Hormone249
- I. Introduction250
- II. Psychological Significance of NHE1251
- III. Na+/H+ Exchanger Basic Structure254
- IV. General Aspects of Regulation of Expression of NHE1255
- V. Initial Studies on Cloning and Characterization of the Mouse NHE1 Promoter256
- VI. Regulation of NHE1 by Thyroid Hormone257
- VII. Summary and Future Directions261
- References262
- Chapter 10. Plasma Retinol-Binding Protein: Structure and Interactions with Retinol, Retinoids, and271
- I. Introduction272
- II. High-Resolution Structure of Retinol-Binding Protein in Complex with Retinol276
- III. Structure of Apo Retinol-Binding Protein281
- IV. Structure of Retinol-Binding Protein in Complex with Retinoids283
- V. Structure of the Retinol-Binding Protein–Transthyretin Complex287
- VI. Summary and Conclusions291
- References292
- Chapter 11. Role of Magnesium, Coenzyme Q10, Riboflavin, and Vitamin B12 in Migraine Prophylaxis297
- I. Introduction298
- II. Magnesium300
- III. Coenzyme Q10301
- IV. Riboflavin302
- V. Vitamin B12 and Homocysteine303
- VI. Conclusions307
- References308
- Index313
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
*First published in 1943, Vitamins and Hormones is AP's longest running serial
*Each volume contains cutting edge reviews by leading contributors
*First published in 1943, Vitamins and Hormones is AP's longest running serial
*Each volume contains cutting edge reviews by leading contributors