Elsevier S & T

Wnt Signaling in Embryonic Development

Sokol, Sergei

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Table of contents
  • Front CoverCover
  • Wnt Signaling in Embryonic Developmentiii
  • Copyright Pageiv
  • Contentsv
  • List of Contributorsvii
  • Prefaceix
  • Common principles and species differencesix
  • Processes involvedx
  • Pathway or network: Variations of different steps in signal transductionxi
  • Looking aheadxii
  • Chapter 1: Wnt/beta-catenin-mediated transcriptional regulation1
  • 1. Introduction3
  • 2. The TCF family as mediators of Wnt/beta-catenin signaling5
  • 3. The "Off state": Repression of Wnt targets in the absence of signaling17
  • 4. The "On State" in the nucleus; Arm/beta-catenin triggers the switch23
  • 5. beta-Catenin-mediated gene repression38
  • 6. Switching off signaling: A nuclear role for the destruction complex41
  • 7. Concluding remarks45
  • References45
  • Chapter 2: Wnt signaling and the establishment of cell polarity61
  • 1. Wnt-signaling pathways62
  • 2. Apical-basal and Planar Cell Polarity63
  • 3. Regulation of apical-basal polarity by Wnt signaling65
  • 4. PCP signaling in the Drosophila wing69
  • 5. PCP signaling in the Drosophila eye72
  • 6. PCP signaling is conserved in mammalian epithelium74
  • 7. Noncanonical Wnt signaling and polarized cell movements77
  • 8. Wnt signaling and asymmetric cell division80
  • 9. A new model system for PCP84
  • 10. Future directions85
  • References86
  • Chapter 3: Wnt signaling in C. elegans: New insights into the regulation of POP-1/TCF-mediated activ95
  • 1. Introduction96
  • 2. Wnt signaling in C. elegans: Pathway components97
  • 3. A canonical Wnt pathway regulates Hox gene expression98
  • 4. Wnt/MAPK signaling101
  • 5. P2/EMS signaling: Spindle orientation and endoderm induction101
  • 6. T cell polarity104
  • 7. Z1/4 polarity: Axis determination in the somatic gonad104
  • 8. Multiple mechanisms regulate POP-1 transcriptional activity105
  • References107
  • Chapter 4: The Wnt-signaling pathways in mammalian patterning and morphogenesis111
  • 1. Introduction113
  • 2. The canonical Wnt pathway in mammalian patterning113
  • 3. The noncanonical Wnt pathway in mammalian morphogenesis140
  • 4. Summary145
  • References145
  • Chapter 5: Cell migration under control of Wnt-signaling in the vertebrate embryo159
  • 1. Introduction160
  • 2. Modes of cell migration in the vertebrate embryo161
  • 3. Cell migration in the early embryo163
  • 4. Neuronal migration181
  • 5. Cell migration in eye development183
  • 6. Heart development187
  • 7. Conclusions191
  • Acknowledgments192
  • References192
  • Chapter 6: Multiple roles for Wnt signaling in the development of the vertebrate neural crest203
  • 1. Introduction204
  • 2. Wnt signals and neural crest induction205
  • 3. Expression of Wnt ligands and receptors206
  • 4. Gain- and loss-of-function studies207
  • 5. Wnt signals and a hierarchy of regulatory steps208
  • 6. Wnt signals in delamination and the onset of migration210
  • 7. Wnt signals and neural crest cell fate diversification214
  • 8. Conclusions and future directions217
  • Acknowledgments217
  • References218
  • Chapter 7: Wnt pathways in angiogenesis223
  • 1. Angiogenesis: A brief introduction224
  • 2. Wnts and Frizzleds in vascular biology225
  • 3. Wnt signaling and pathological angiogenesis226
  • 4. Norrin, a new player in the field228
  • 5. Wnt regulation of angiogenesis231
  • 6. Current perspectives233
  • References234
  • Index239
Book details
  • Vendor Elsevier S & T
  • SKU 9780444528742
  • ISBN-13 9780080471341
  • Author Sokol, Sergei
  • Category Science
  • Subject Developmental Biology

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Description eBook delivery & access Reviews
A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes.

* Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton
* Offers insight to large genomic data that are now available for the analysis of Wnt gene targets
* Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity