Elsevier S & T

WTEC Panel Report on Tissue Engineering Research

McIntire, Larry V.

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Table of contents
  • Cover
  • Table of Contentsix
  • Forewordxiii
  • List of Figuresxvii
  • List of Tablesxix
  • Executive Summaryxxi
  • Chapter 1. Introduction1
  • Background: The Significance of Tissue Engineering1
  • History of Tissue Engineering1
  • Promise of Tissue Engineering2
  • Other Applications3
  • Emerging Industry of Tissue Engineering3
  • Objectives of the WTEC Study3
  • Scope and Methodology4
  • Vision for the Future6
  • Acknowledgements6
  • References7
  • Chapter 2. Biomaterials9
  • Introduction9
  • U.S. R&D Activities12
  • Japanese R&D Activities16
  • European R&D Activities17
  • Summary19
  • References21
  • Chapter 3. Cells23
  • Introduction23
  • Analysis of Current State of the Art and Factors Influencing Progress23
  • Control of Cell Proliferation and Differentiation27
  • U.S. R&D Activities28
  • Background28
  • Current Efforts29
  • Future Position32
  • R&D Activities in Europe33
  • Japan34
  • Summary35
  • References36
  • Chapter 4. Biomolecules41
  • Introduction41
  • Gene Transfer42
  • Angiogenic Factors/Growth Factors48
  • Differentiation Factors55
  • Bone Morphogenic Proteins56
  • References58
  • Chapter 5. Cell-Based Technologies: Non-Medical Applications61
  • Introduction61
  • Overview of R&D Activities63
  • Summary66
  • Chapter 6. Engineering Design Aspects of Tissue Engineering71
  • Introduction71
  • Bioreactor Technology72
  • Preservation o f Cells and Engineered Tissues74
  • Mass Transport Issues Following Implantation75
  • Biomechanics Issues77
  • Summary80
  • References81
  • Chapter 7. Informatics and Tissue Engineering83
  • Introduction83
  • Informatics Components That Will Ultimately Support Tissue Engineering86
  • U.S. R&D Activities90
  • European R&D Activities90
  • Japanese R&D Activities92
  • Summary93
  • References94
  • Chapter 8. Legal and Regulatory Issues97
  • Introduction97
  • FDA Regulation98
  • Other Considerations Relevant to Engineered Tissues109
  • Regulation of Pharmaceutical/Medical Human Tissue Products in Europe111
  • Regulation of Pharmaceutical/Medical Human Tissue Products in Japan113
  • Conclusion115
  • References116
  • APPENDICES117
  • A. Biographies of Panelists117
  • B. Site Reports„Europe122
  • C. Appendix C. Site Reports„Japan190
  • D. Summary of the June 2000 U.S. Review Workshop240
  • E. The Federal Investment in Tissue Engineering262
Book details
  • Vendor Elsevier S & T
  • SKU 9780124841505
  • ISBN-13 9780080543871
  • Author McIntire, Larry V.
  • Category Science
  • Subject Biotechnology

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WTEC Panel Report on Tissue Engineering Research